Weekly Journal Club Highlight Exploring Pseudoislets from Insulinoma Cells
4/1/20251 min read
At Islet Nexus, our passion for collaborative discovery comes alive during our weekly journal club meetings—where lab members and visiting students come together to discuss exciting advancements in islet biology.
This week, we’re highlighting a presentation by Harshdeep, a medical student currently rotating in our lab, who recently led a fascinating discussion on pseudoislet formation using murine insulinoma cell lines. The study, published in Cell Transplantation, describes an efficient method for generating 3D pseudoislets from MIN6 and NIT-1 cells. These clusters not only mimic native islet architecture but also retain the ability to secrete insulin in response to glucose and can be tracked in vivo using bioluminescence imaging.
Harshdeep’s presentation sparked an engaging conversation about the potential of pseudoislets in diabetes research—especially their value in standardized, scalable, and trackable transplantation models. As our team explores novel cell therapies, methods like these provide a strong foundation for advancing both basic science and translational applications.
We’re thrilled to support emerging scientists like Harshdeep and celebrate the energy they bring to the field.
Stay tuned for next week’s journal club insights, and don’t forget to check out the full article here:
Tags: #JournalClub #IsletResearch #StudentSpotlight #RegenerativeMedicine