IsletNexus Research Publications

Explore our extensive research publications showcasing advancements in diabetes, stem cell therapy, and beta-cell failure mechanisms by our dedicated team.

El Muayed M, Wang JC, Wong WP, Metzger BE, Zumpf KB, Gurra MG, Sponenburg RA, Hayes MG, Scholtens DM, Lowe LP, Lowe Jr WL. Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS). J Expo Sci Environ Epidemiol 2023;33(6):855-64. PMID: 36509832

Bailey J, Lavelle B, Miller J, Jimenez M, Lim PH, Orban ZS, Clark JR, Tomar R, Ludwig A, Ali ST, Lank GK, Zielinski A, Mylvaganam R, Kalhan R, El Muayed M, Mutharasan RK, Liotta EM, Sznajder JI, Davidson C, Koralnik IJ, Sala MA. Multidisciplinary Center Care for Long COVID Syndrome–a Retrospective Cohort Study Am J. of Medicine. 2023; e-pub ahead of print PMID: 37220832

Wong WP, Wang JC, Meyers MS, Wang NJ, Sponenburg RA, Allen NB, Edwards JE, El Muayed M. A Novel Chronic in vivo Oral Cadmium Exposure-Washout Mouse Model for Studying Cadmium Toxicity and Complex Diabetogenic Effects. Toxicol and Appl Pharmacol 2022; 447: 116057; PMID: 35550884

Wong WP, Wang JC, Schipma MJ, Zhang X, Edwards JR, El Muayed M. Cadmium-mediated pancreatic islet transcriptome changes in mice and cultured mouse islets. Toxicol and Appl Pharmacol 2021 Dec;433:115756; PMID: 34666113

Wang J, Wong WP, Link EO, Olivares S, Adelman CT, Henkel AS, El Muayed M. Single well, single-common primer pair, dual probe, duplex qPCR assay for the quantification of mRNA splicing variants. Biol Methods Protoc 2021 May;6(1); PMID: 33655078

Fitzgerald R, Olsen A, Nguyen J, Wong W, El Muayed M, Edwards J. Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia. Int J Mol Sci 2020 Dec;22(1); PMID: 33396420

Wallia A, Prince G, Touma E, El Muayed M, Seley JJ. Caring for Hospitalized Patients with Diabetes Mellitus, Hyperglycemia, and COVID-19: Bridging the Remaining Knowledge Gaps. Curr Diab Rep 2020 Nov;20(12):77; PMID: 33244614

Wong WP, Allen NB, Meyers MS, Link EO, Zhang X, MacRenaris KW, El Muayed M. Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel. Scientific Reports 2017 Mar;7(1):473; PMID: 28352089

Wong WP, Wallia A, Edwards JR, El Muayed M. Comment on Menke et al. Metals in Urine and Diabetes in U.S. Adults. Diabetes 2016;65:164-171. Diabetes 2016 Sep;65(9):e31; PMID: 27555580

Kashiv Y, Austin JR, Lai B, Rose V, Vogt S, El Muayed M. Imaging trace element distributions in single organelles and subcellular features. Scientific Reports 2016 Feb;6:21437; PMID: 26911251

Vellanki P, Lange K, Elaraj D, Kopp PA, El Muayed M. Denosumab for management of parathyroid carcinoma-mediated hypercalcemia. J Clin Endocrinol Metab 2014 Feb;99(2):387–390. PMID: 24178790

Wallia A, Allen NB, Badon S, El Muayed M. Association between urinary cadmium levels and prediabetes in the NHANES 2005-2010 population. Int J Hyg Environ Health 2014 Nov;217(8):854–860; PMID: 25043455

Ruusuvuori E, Huebner AK, Kirilkin I, Yukin AY, Blaesse P, Helmy M, Kang HJ, El Muayed M, Hennings JC, Voipio J, Šestan N, Hübner CA, Kaila K. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO Journal 2013 Aug;32(16):2275–2286; PMID: 23881097

El Muayed M, Raja MR, Zhang X, MacRenaris KW, Bhatt S, Chen X, Urbanek M, O’Halloran TV, Lowe WL. Accumulation of cadmium in insulin-producing β cells. Islets 2012 Nov;4(6):405–416; PMID: 23466887

El Muayed M, Lowe WL. The beta and alpha cell-specific Znt8-knockout mouse model: new mechanistic insights? Diabetologia 2011 Jan;54(1):207–208; PMID: 20953582

El Muayed M, Billings LK, Raja MR, Zhang X, Park PJ, Newman MV, Kaufman DB, O’Halloran TV, Lowe WL. Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J Endocrinol2010 Aug;206(2):159–169; PMID: 20508080

El Muayed M, Costas AA, Pick AJ. 1,25-Dihydroxyvitamin D-mediated hypercalcemia in oleogranulomatous mastitis (paraffinoma), ameliorated by glucocorticoid administration. Endocr Pract 2010 Jan;16(1):102–106. [PMID: 19625241], cited 10 times (Google Scholar)/ 5 times (Web of Science).

El Muayed, M: Comment on: "Angiotensin-Converting Enzyme Inhibition in Hypertensive Patients is Associated with a Reduction in the Occurrence of Atrial Fibrillation J Am Coll Cardiol 2005; 45(7):1144. PMID: 15808777

El Muayed M, Burjonroppa SC, Croitoru M: Added Accuracy with 3D Echocardiographic Imaging of Valvular Vegetations. Echocardiography 2005; 22(4):361-2. PMID: 15839994

El Muayed M, Lavis VR, Safi HJ, Fuentes F: Use of Glitazones in Cardiac Patients: a Case for B-Type Natriuretic Peptide Monitoring? Am J Cardiol. 2004; 93(5):600-2. PMID: 14996586

El Muayed M, Stegbauer J, Oberhauser V, Vonend O, Rump LC: AT1 and AT2-receptor antagonists inhibit Angiotensin II-mediated facilitation of noradrenaline release in human atria. J Cardiovasc Pharmacol 2004; 43(2):318-24; PMID: 14716224

Chichura KS, Elfers CT, Salameh TS, Kamat V, Chepurny OG, McGivney A, Milliken BT, Holz GG, Applebey SV, Hayes MR, Sweet IR, Roth CL, Doyle RP. A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss. Sci Rep. 2023 Jun 12;13(1):9554. doi: 10.1038/s41598-023-36178-1. PMID: 37308546; PMCID: PMC10261008.

Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. PMID: 37339634; PMCID: PMC10834355.

Liles A, Cham N, Opp ML, Tinsley IC, Chepurny OG, Holz GG, Doyle RP. Corrination mitigates peptide aggregation as exemplified for Glucagon. Peptides. 2024 Jan;171:171134. doi: 10.1016/j.peptides.2023.171134. Epub 2023 Dec 12. PMID: 38092266; PMCID: PMC10842878.

Cabrera O, Ficorilli J, Shaw J, Echeverri F, Schwede F, Chepurny OG, Leech CA, Holz GG. Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon. J Biol Chem. 2022 Feb;298(2):101484. doi: 10.1016/j.jbc.2021.101484. Epub 2021 Dec 9. PMID: 34896391; PMCID: PMC8789663.