IsletNexus Research Publications

Explore our extensive research publications showcasing advancements in diabetes, stem cell therapy, and beta-cell failure mechanisms by our dedicated team.

Turan GA, Delibasi T. Gestational Diabetes and Infertility. Journal of Diabetes Mellitus. 2023 May;13 (2): 203-221

Lacroix A, Bronstein MD, Schopohl J, Delibasi T, Salvatori R, Li Y, Barkan A, Suzaki N, Tauchmanova L, Ortmann CE, Ravichandran S, Petersenn S, Pivonello R. Long-acting pasireotide improves clinical signs and quality of life in Cushing's disease: results from a phase III study. J Endocrinol Invest. 2020. Nov;43 (11):1613-1622

Pagidipati NJ, Zheng Y, Green JB, McGuire DK, Mentz RJ, Shah S, Aschner P, Delibasi T, Rodbard HW, Westerhout CM, Holman RR, Peterson ED; TECOS Study Group. Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS. Is Heart J. 2020 Jan; 219:47-57?

Nauck MA, McGuire DK, Pieper KS, Lokhnygina Y, Strandberg TE, Riefflin A, Delibasi T, Peterson ED, White HD, Scott R, Holman RR. Sitagliptin does not reduce the risk of cardiovascular death or hospitalization for heart failure following myocardial infarction in patients with diabetes: observations from TECOS. Cardiovasc Diabetol. 2019 Sep 3;18(1):116

Lacroix A, Gu F, Gallardo W, Pivonello R, Yu Y, Witek P, Boscaro M, Salvatori R, Yamada M, Tauchmanova L, Roughton M, Ravichandran S, Petersenn S, Biller BMK, Newell-Price J; Pasireotide G2304 Study Group. Efficacy and safety of once monthly pasireotide in Cushing's disease: a 12-month clinical trial. Lancet Diabetes Endocrinol. 2018 Jan;6(1):17-26.

Pagidipati NJ, Navar AM, Pieper KS, Green JB, Bethel MA, Armstrong PW, Josse RG, McGuire DK, Lokhnygina Y, Cornel JH, Halvorsen S, Strandberg TE, Delibasi T, Holman RR, Peterson ED; TECOS Study Group. Secondary Prevention of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus: International Insights Fromthe TECOS Trial (Trial Evaluating Cardiovascular Outcomes with Sitagliptin). Circulation. 2017 Sep 26;136(13):1193-1203.

Senturk B, Demircan BM, Ozkan AD, Tohumeken S, Delibasi T, Guler MO, Tekinay AB. Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel indb/db mice. Biomater Sci. 2017 Jun 27;5(7):1293-1303

le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, Ortiz RV, Wilding JPH, Skjøth TV, Manning LS, Pi-Sunyer X; SCALE Obesity Prediabetes NN8022-1839 Study Group. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomized, double-blind trial. Lancet. 2017 Apr 8;389(10077):1399-1409.

Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML, Woo V, Hansen O, Holst AG, Pettersson J, Vilsbøll T; SUSTAIN-6 Investigators. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844.

Arslan MS, Tutal E, Sahin M, Karakose M, Ucan B, Ozturk G, Cakal E, Biyikli, Gencturk Z, Ozbek M, Delibasi T. Effect of lifestyle interventions with or without metformin therapy on serum levels of osteoprotegerin and receptor activator of nuclear factor kappa B ligand in patients with prediabetes. Endocrine. 2016 Oct 15.

El Muayed, M: Comment on: "Angiotensin-Converting Enzyme Inhibition in Hypertensive Patients is Associated with a Reduction in the Occurrence of Atrial Fibrillation J Am Coll Cardiol 2005; 45(7):1144. PMID: 15808777

El Muayed M, Burjonroppa SC, Croitoru M: Added Accuracy with 3D Echocardiographic Imaging of Valvular Vegetations. Echocardiography 2005; 22(4):361-2. PMID: 15839994

El Muayed M, Lavis VR, Safi HJ, Fuentes F: Use of Glitazones in Cardiac Patients: a Case for B-Type Natriuretic Peptide Monitoring? Am J Cardiol. 2004; 93(5):600-2. PMID: 14996586

El Muayed M, Stegbauer J, Oberhauser V, Vonend O, Rump LC: AT1 and AT2-receptor antagonists inhibit Angiotensin II-mediated facilitation of noradrenaline release in human atria. J Cardiovasc Pharmacol 2004; 43(2):318-24; PMID: 14716224

A-kinase regulator runs amok to provide a paradigm shift in cAMP signaling. Journal of Biological Chemistry, 2019. This is an Editor's Pick Highlight concerning the published JBC paper of Adame-Garcia et al. (2019) for which the Holz laboratory provided a commissioned commentary.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput assays for cAMP. Journal of Biological Chemistry, 2019. This collaborative study using computational molecular modeling and FRET-based assays for cAMP revealed the promiscuous nature of glucagon and GLP-1 receptor agonist and antagonist action at family B GPCRs.

Chichura KS, Elfers CT, Salameh TS, Kamat V, Chepurny OG, McGivney A, Milliken BT, Holz GG, Applebey SV, Hayes MR, Sweet IR, Roth CL, Doyle RP. A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss. Sci Rep. 2023 Jun 12;13(1):9554. doi: 10.1038/s41598-023-36178-1. PMID: 37308546; PMCID: PMC10261008.

Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. PMID: 37339634; PMCID: PMC10834355.

Liles A, Cham N, Opp ML, Tinsley IC, Chepurny OG, Holz GG, Doyle RP. Corrination mitigates peptide aggregation as exemplified for Glucagon. Peptides. 2024 Jan;171:171134. doi: 10.1016/j.peptides.2023.171134. Epub 2023 Dec 12. PMID: 38092266; PMCID: PMC10842878.

Cabrera O, Ficorilli J, Shaw J, Echeverri F, Schwede F, Chepurny OG, Leech CA, Holz GG. Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon. J Biol Chem. 2022 Feb;298(2):101484. doi: 10.1016/j.jbc.2021.101484. Epub 2021 Dec 9. PMID: 34896391; PMCID: PMC8789663.

Paz-Filho GJ, Delibasi T, Erol HK, Wong ML, Licinio J. Cellular Immunity Before and After Leptin Replacement Therapy. J Pediatr Endocrinol Metab, 22, 1069-1074 (2009)

Paz-Filho G, Delibasi T, Erol HK, Wong ML, Licino J. Congenital Leptin Deficiency and Thyroid Function. Thyroid Res, 4, 11 (2009).